TACC3 inhibitor 1
TACC3 inhibitor 1 is a potent and cross the blood-brain barrier TACC3 inhibitor. TACC3 inhibitor 1 induces Apoptosis and cell cycle arrest at G2/M phase. TACC3 inhibitor 1 induces the generation of intracellular ROS. TACC3 inhibitor 1 shows antiproliferative and anti-tumor activity[1].
Product Specifications
CAS Number
3033646-06-6
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tacc3-inhibitor-1.html
Solubility
10 mM in DMSO
Smiles
OC1CC2CC1CN2C3=CC=NC(NCC4=CSC(C5=CC=CC=C5)=N4)=N3
Molecular Formula
C20H21N5OS
Molecular Weight
379.48
References & Citations
[1]Zhao W, et al. Discovery of novel analogs of KHS101 as transforming acidic coiled coil containing protein 3 (TACC3) inhibitors for the treatment of glioblastoma. Eur J Med Chem. 2022 Dec 15;244:114874.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC681081-500 1x 500 µL
CD45RO (190-2F2.5), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC472748-500 1x 500 µL
AMACR / p504S (Prostate Cancer Marker) (AMACR/2748R), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC470857-100 1x 100 µL
WT1 (Wilm's Tumor 1) (WT1/857), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC401237-500 1x 500 µL
P27 / KIP1 (DCS-72.F6 + KIP1/769 (SX53G8) ), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details