Tubulin polymerization-IN-39
Tubulin polymerization-IN-39 is a tubulin polymerization inhibitor (IC50: 4.9 μM) . Tubulin polymerization-IN-39 occupies the colchicine-binding site. Tubulin polymerization-IN-39 inhibits cancer cell proliferation[1].
Product Specifications
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/tubulin-polymerization-in-39.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C=C1O)C2=CC=NC3=NC(NC4=CC(OC)=C(C(OC)=C4)OC)=NN23
Molecular Formula
C21H21N5O5
Molecular Weight
423.42
References & Citations
[1]Chen L, et al. Rational design, synthesis and biological evaluation of novel 2- (substituted amino) -[1,2,4]triazolo[1,5-a]pyrimidines as novel tubulin polymerization inhibitors. Eur J Med Chem. 2022 Dec 15;244:114864.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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