Mps1-IN-5
Mps1-IN-5 is a potent and orally active Mps1 inhibitor with an IC50 value of 29 nM. Mps1-IN-5 induces Apoptosis and cell cycle arrests at G2/M phase. Mps1-IN-5 shows antiproliferative activity and anti-tumor activity. Mps1-IN-5 inhibits phosphorylation of Mps1 and induces DNA damage[1].
Product Specifications
CAS Number
[2890819-31-3]
UNSPSC
12352005
Target
Apoptosis; Mps1
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mps1-in-5.html
Solubility
10 mM in DMSO
Smiles
CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC4=C(C(N5N=C(C6=CC=CC=C65)N)=N3)C=CN4
Molecular Formula
C24H25N9
Molecular Weight
439.52
References & Citations
[1]Li X, et al. Design, synthesis and biological evaluation of a new class of 7H-pyrrolo[2,3-d]pyrimidine derivatives as Mps1 inhibitors for the treatment of breast cancer. Eur J Med Chem. 2023 Jan 5;245 (Pt 1) :114887.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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