VEGFR-2-IN-30
VEGFR-2-IN-30 is a VEGFR-2 inhibitor (IC50: 66 nM) . VEGFR-2-IN-30 also inhibits PDGFR, EGFR and FGFR1 with IC50s of 180, 98, 82 nM respectively. VEGFR-2-IN-30 arrests cancer cell at S-phase and induces early and late apoptosis[1].
Product Specifications
UNSPSC
12352005
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vegfr-2-in-30.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(C=C1)S(=O)(NC2=NN=C(C=C2)Cl)=O)CSC3=NC4=CC=CC=C4C(N3CCC5=CC=CC=C5)=O
Molecular Formula
C28H23ClN6O4S2
Molecular Weight
607.10
References & Citations
[1]Zahran SS, et al. Antiproliferative, antiangiogenic and apoptotic effect of new hybrids of quinazoline-4 (3H) -ones and sulfachloropyridazine. Eur J Med Chem. 2023 Jan 5;245 (Pt 1) :114912.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1
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