PPARγ/GR modulator 1

PPARγ/GR modulator 1 is an orally active dual agonist of PPARγ and glucocorticoid receptor (GR), with Kis of 3.3 and 33.6 μM, respectively. PPARγ/GR modulator 1 can be used for the research of metabolic diseases, such as diabetes[1].

Product Specifications

UNSPSC

12352005

Target

Glucocorticoid Receptor; PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/pparγ-gr-modulator-1.html

Solubility

10 mM in DMSO

Smiles

CC(OC1=O)=CC(O)=C1C(/C=C/C2=CC=NC(F)=C2)=O

Molecular Formula

C14H10FNO4

Molecular Weight

275.23

References & Citations

[1]Ahn S, et, al. Discovery of PPARγ and glucocorticoid receptor dual agonists to promote the adiponectin and leptin biosynthesis in human bone marrow mesenchymal stem cells. Eur J Med Chem. 2023 Jan 5;245 (Pt 1) :114927.