ALR2-IN-2

ALR2-IN-2 is a potent inhibitor of aldose reductase (ALR2), with IC50s of 27 nM and 228 nM for rat ALR2 and ALR1, respectively. ALR2-IN-2 can be used for the research of diabetic complications[1].

Product Specifications

UNSPSC

12352005

Target

Aldose Reductase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/alr2-in-2.html

Solubility

10 mM in DMSO

Smiles

FC1=CC=C(C=C1)/C=N/N2C(/C(SC2=S)=C/C3=CC=C(C=C3)O)=O

Molecular Formula

C17H11FN2O2S2

Molecular Weight

358.41

References & Citations

[1]Kratky M, et, al. Novel rhodanine based inhibitors of aldose reductase of non-acidic nature with p-hydroxybenzylidene functional group. Eur J Med Chem. 2022 Nov 12;246:114922.