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TRK II-IN-1

TRK II-IN-1 is a potent type II TRK inhibitor, with IC50s of 3.3, 6.4, 4.3 and 9.4 nM, for TRKA/B/C and TRKAG667C, respectively. TRK II-IN-1 also inhibits FLT3, RET, and VEGFR2 with IC50s of 1.3, 9.9, and 71.1 nM, respectively. TRK II-IN-1 can be used for the research of TRK driven cancers[1].

Product Specifications

CAS Number

2904690-41-9

UNSPSC

12352005

Target

FLT3; RET; Trk Receptor; VEGFR

Type

Reference compound

Related Pathways

Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/trk-ii-in-1.html

Solubility

10 mM in DMSO

Smiles

CN1CCN(CC1)CC2=CC=C(C=C2C(F)(F)F)NC([C@@H]3CCN(C3)C4=NN5C(C6=NC=CC=C6)=CN=C5C=C4)=O

Molecular Formula

C29H31F3N8O

Molecular Weight

564.60

References & Citations

[1]Xiang S, et, al. Switch type I to type II TRK inhibitors for combating clinical resistance induced by xDFG mutation for cancer therapy. Eur J Med Chem. 2023 Jan 5;245 (Pt 1) :114899.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

TrkA; TrkB; TrkC; VEGFR2/KDR/Flk-1

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