MtInhA-IN-1
MtInhA-IN-1 is a selective and orally active Mycobacterium tuberculosis NADH-dependent enoyl-acyl carrier protein reductase (MtInhA) inhibitor with an IC50 of 0.23 μM. MtInhA-IN-1 potently against M. tuberculosis H37Rv strain with a MIC value of 0.4 μM[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mtinha-in-1.html
Solubility
10 mM in DMSO
Smiles
CC1=NC2=C(C(NC3=CC=C(C=C3)N4CCCCC4)=C1)C=C(C=C2)Br
Molecular Formula
C21H22BrN3
Molecular Weight
396.32
References & Citations
[1]Josiane Delgado Paz, et al. Novel 4-aminoquinolines: Synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase, antitubercular activity, SAR, and preclinical evaluation. Eur J Med Chem. 2023 Jan 5;245 (Pt 1) :114908.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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