BLM-IN-2
Product Specifications
UNSPSC Description
BLM-IN-2 is a Bloom's Syndrome Protein (BLM) inhibitor with an IC50 value of 0.8 μM. BLM-IN-2 effectively suppresses the proliferation, invasion, cell cycle arrest and apoptosis of CRC cells. BLM-IN-2 can be used for the reserarch of colorectal cancer (CRC)[1].
Target Antigen
Apoptosis; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/blm-in-2.html
Solubility
10 mM in DMSO
Smiles
CCN(CCCNC1=C(C=C2C(N(C(/C=C/C3=CC=C(C=C3)C(C)C)=NC2=C1)CC4=CC=C(C=C4)Br)=O)F)CC
Molecular Weight
605.58
References & Citations
[1] Jia-Li Tu, et al. Design, synthesis and evaluation of N3-substituted quinazolinone derivatives as potential Bloom's Syndrome protein (BLM) helicase inhibitor for sensitization treatment of colorectal cancer. Eur J Med Chem. 2022 Nov 21;246:114944.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-151939/BLM-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-151939/
Clinical Information
No Development Reported
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