Reverse transcriptase-IN-3

Reverse transcriptase-IN-3 is a pyrimidine-5-carboxamide derivative, acts as an inhibitor of HIV-1. Reverse transcriptase-IN-3 shows potent activity against the HIV-1 wild-type and mutant strains[1].

Product Specifications

UNSPSC

12352005

Target

HIV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/reverse-transcriptase-in-3.html

Solubility

10 mM in DMSO

Smiles

CC1=CC(C#N)=CC(C)=C1OC2=C(C=NC(NC3CCN(CC3)C4=CC=C(C=C4)NS(=O)(C5CC5)=O)=N2)C(N)=O

Molecular Formula

C28H31N7O4S

Molecular Weight

561.66

References & Citations

[1]Feng D, et al. Disubstituted pyrimidine-5-carboxamide derivatives as novel HIV-1 NNRTIs: Crystallographic overlay-based molecular design, synthesis, and biological evaluation. Eur J Med Chem. 2022 Nov 22;246:114957.