Antileishmanial agent-13

Antileishmanial agent-13 is a quinoline-isatin hybrid, acts as an antileishmanial agent against L. Major Leishmania strain. Antileishmanial agent-13 acquires the antileishmanial activity via the anti-folate mechanism. Antileishmanial agent-13 has potent inhibition against both promastigote and amastigote forms with IC50s of 0.604 μM and 0.508 μM, respectively[1].

Product Specifications

CAS Number

[853725-86-7]

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/antileishmanial-agent-13.html

Solubility

10 mM in DMSO

Smiles

O=C1NC2=C(/C1=N\NC3=CC=NC4=CC(Cl)=CC=C43)C=C(C=C2)Br

Molecular Formula

C17H10BrClN4O

Molecular Weight

401.64

References & Citations

[1]Sabt A, et al. New antileishmanial quinoline linked isatin derivatives targeting DHFR-TS and PTR1: Design, synthesis, and molecular modeling studies[J]. European Journal of Medicinal Chemistry, 2022: 114959.