HIV-1 inhibitor-49
HIV-1 inhibitor-49 is an orally active HIV-1 inhibitor, is a HEPT analog. HIV-1 inhibitor-49 possesses great pharmacokinetics profiles and potent non-nucleoside reverse transcriptase inhibitory activity (IC50=30 nM) . HIV-1 inhibitor-49 exerts potential safety without acute toxicity in mouse model[1].
Product Specifications
UNSPSC
12352005
Target
HIV; Reverse Transcriptase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/hiv-1-inhibitor-49.html
Solubility
10 mM in DMSO
Smiles
O=C1NC(N(C(SC2=CC(F)=CC=C2F)=C1C3CC3)COCC4=CC=CC=C4)=O
Molecular Formula
C21H18F2N2O3S
Molecular Weight
416.44
References & Citations
[1]Zhou RL, et al. Structure-guided design of novel HEPT analogs with enhanced potency and safety: From Isopropyl-HEPTs to Cyclopropyl-HEPTs. Eur J Med Chem. 2022 Nov 24;246:114939.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1
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