D6808
D6808 is a highly selective and potent c‑Met inhibitor with an IC50 value of 2.9 nM. D6808 induces cell apoptosis and cell cycle arrest. D6808 can be used for the research of NSCLC and gastric cancers[1].
Product Specifications
CAS Number
3029240-84-1
UNSPSC
12352005
Target
C-Met/HGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/d6808.html
Solubility
10 mM in DMSO
Smiles
O=C1NCCCCN2C=C(C3=CN=C4C=CC(CCN5N=C(C6=CC(C(F)(F)F)=C1C=C6)C=CC5=O)=CC4=C3)C=N2
Molecular Formula
C30H25F3N6O2
Molecular Weight
558.55
References & Citations
[1]Wang C, et al. Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment. J Med Chem. 2022 Nov 24;65 (22) :15140-15164.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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