SARS-CoV-2 Mpro-IN-5
SARS-CoV-2 Mpro-IN-5 is a dual Inhibitor of Main Protease (MPro) and Cathepsin L (CatL), with IC50s of 1800 nM and 145 nM respectively. SARS-CoV-2 Mpro-IN-5 has antiviral activity against SARS-CoV2. SARS-CoV-2 Mpro-IN-5 blocks SARS-CoV2 replication in hACE2 expressing A549 cells with IC50 value of 14.7 nM[1].
Product Specifications
CAS Number
3023276-79-8
UNSPSC
12352005
Target
SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/sars-cov-2-mpro-in-5.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H](NC(OC(C)(C)C)=O)CC1=CC=C(F)C=C1)N[C@H](C(N[C@@H](C[C@@H]2CCNC2=O)/C=C/C(OCC)=O)=O)CC3=CC=CC=C3
Molecular Formula
C34H43FN4O7
Molecular Weight
638.73
References & Citations
[1]Mondal S, et al. Dual Inhibitors of Main Protease (MPro) and Cathepsin L as Potent Antivirals against SARS-CoV2. J Am Chem Soc. 2022 Nov 23;144 (46) :21035-21045.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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