A3AR modulator 1
A3AR modulator 1 (MRS8054) is an orally active A3 adenosine receptor (A3AR) (Adenosine Receptor) positive allosteric modulator (PAM) . A3AR modulator 1 greatly enhances Cl-IB-MECA-stimulated [35S]GTPγS binding Emax[1].
Product Specifications
CAS Number
2991693-62-8
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/a3ar-modulator-1.html
Solubility
10 mM in DMSO
Smiles
CCCC(C1=NC2=C(C3=C(N=C2NC4=CC=C(C=C4)I)C=CC=C3)N1)CCC
Molecular Formula
C23H25IN4
Molecular Weight
484.38
References & Citations
[1]Lucas B Fallot, e al. Structure-Activity Studies of 1 H-Imidazo[4,5- c]quinolin-4-amine Derivatives as A3 Adenosine Receptor Positive Allosteric Modulators. J Med Chem. 2022 Nov 24;65 (22) :15238-15262.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Adenosine A3 receptor (A3R)
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