HDAC6-IN-14
HDAC6-IN-14 is a highly selective HDAC6 (HDAC) inhibitor with an IC50 of 42 nM. HDAC6-IN-14 displays >100-fold selectivity over HDAC1/HDAC2/HDAC3/HDAC4[1].
Product Specifications
CAS Number
3023019-97-5
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac6-in-14.html
Solubility
10 mM in DMSO
Smiles
O=C(NO)C1=CC=C(CN(CC(NC(C)(C)C)=O)C(C2=CC=CC=C2C(C)C)=O)C(F)=C1
Molecular Formula
C24H30FN3O4
Molecular Weight
443.51
References & Citations
[1]Nina Reßing, et al. Development of Fluorinated Peptoid-Based Histone Deacetylase (HDAC) Inhibitors for Therapy-Resistant Acute Leukemia. J Med Chem. 2022 Nov 24;65 (22) :15457-15472.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC2; HDAC3; HDAC4; HDAC6
Frequently Asked Questions
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