Dual AChE-MAO B-IN-3
Dual AChE-MAO B-IN-3 (compound C10) is a potent dual AChE/MAO-B inhibitior, with IC50 values of 0.58 and 0.41 μM, respectively. Dual AChE-MAO B-IN-3 is a dual-binding inhibitor bound to both the catalytic anionic site and peripheral anionic site of AChE. Dual AChE-MAO B-IN-3 can be used for Alzheimer’s disease (AD) research[1].
Product Specifications
UNSPSC
12352005
Target
Cholinesterase (ChE) ; Monoamine Oxidase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dual-ache-mao-b-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(/C(CO1)=C/C2=CCN(CC2)CC3=CC=CC=C3)C(C=C4)=C1C=C4OCC(C=C5)=CC=C5C(F)(F)F
Molecular Formula
C30H26F3NO3
Molecular Weight
505.53
References & Citations
[1]Li X, et al. Design, Synthesis, and Biological Evaluation of Novel Chromanone Derivatives as Multifunctional Agents for the Treatment of Alzheimer's Disease. ACS Chem Neurosci. 2022 Nov 16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; MAO-B
Frequently Asked Questions
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