APE1-IN-2
APE1-IN-2 (compound AP1) is a Pt (IV) proagent, targeting a critical BER protein, apurinic/apyrimidinic endonuclease 1 (APE1) . APE1-IN-2 shows anticancer activity. APE1-IN-2 induces intracellular accumulation of platinum and activates DNA damage response and apoptosis signals[1].
Product Specifications
CAS Number
[2923433-95-6]
UNSPSC
12352005
Target
Apoptosis; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ape1-in-2.html
Purity
98.28
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[Pt](Cl)(Cl)(OC(C1=CC2=CC=CC([N+]([O-])=O)=C2N1)=O)([NH3])[NH3]
Molecular Formula
C9H12Cl2N4O5Pt
Molecular Weight
522.21
References & Citations
[1]Yuan Y, et al. Pt (IV) Prodrug as a Potential Antitumor Agent with APE1 Inhibitory Activity. J Med Chem. 2022 Nov 24;65 (22) :15344-15357.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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