Antibacterial agent 124

Antibacterial agent 124 (Compound 3) is a potent bacterial prolyl-tRNA synthetase (ProRS) inhibitor with an IC50 of 0.18 μM against Staphylococcus aureus ProRS (SaProRS) [1].

Product Specifications

CAS Number

[2304448-00-6]

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/antibacterial-agent-124.html

Solubility

10 mM in DMSO

Smiles

O=C(CN1C=NC2=CC(Cl)=C(C=C2C1=O)F)C[C@@H]3CCCCN3

Molecular Formula

C16H17ClFN3O2

Molecular Weight

337.78

References & Citations

[1]Cheng B, et al. Structure-Guided Design of Halofuginone Derivatives as ATP-Aided Inhibitors Against Bacterial Prolyl-tRNA Synthetase. J Med Chem. 2022 Nov 17.