MurA-IN-3
MurA-IN-3 is a reversible pyrrolidinedione-based MurA inhibitor. MurA-IN-3 has inhibitory activity for MurA with an IC50 value of 4.5 μM. MurA-IN-3 also has antibacterial activity[1].
Product Specifications
CAS Number
2866186-38-9
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mura-in-3.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=C2N=C(SC2=C1)N3C(C(O)=C(C3C4=CC=C(O4)C5=CC=C(C=C5)Cl)C(OC(C)(C)C)=O)=O
Molecular Formula
C27H23ClN2O5S
Molecular Weight
523.00
References & Citations
[1]Reem K Fathalla, et al. Identification and Biochemical Characterization of Pyrrolidinediones as Novel Inhibitors of the Bacterial Enzyme MurA. J Med Chem. 2022 Nov 10;65 (21) :14740-14763.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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