N3-Gly-Gly-OH (DCHA)
N3-Gly-Gly-OH (DCHA) is a click chemistry reagent. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity[1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
Product Specifications
CAS Number
[2706488-76-6]
UNSPSC
12352211
Target
ADC Linker
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/n3-gly-gly-oh-dcha.html
Solubility
10 mM in DMSO
Smiles
[N-]=[N+]=NCC(NCC(O)=O)=O.C1(CCCCC1)NC2CCCCC2
Molecular Formula
C16H29N5O3
Molecular Weight
339.43
References & Citations
[1]Jiang X, et al. Recent applications of click chemistry in drug discovery. Expert Opin Drug Discov. 2019 Aug;14 (8) :779-789.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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