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H-L-Phe (4-NH-Poc) -OH (hydrochloride)

H-L-Phe (4-NH-Poc) -OH (hydrochloride) is a click chemistry reagent containing an azide group. Used as a modified Phe or Tyr analogue in protein and peptide biosynthesis. Propargyloxycarbonyl, commonly abbreviated as Poc or Pryoc, can either be used as alkyne component for standard Click conjugation or in combination with tetrazine linkers in copper-free Diels-Alder type Click reactions. It also has applications as unusual protecting group for amines, hydroxy functions and as esters. All 3 are stable to neat TFA, but can be cleaved at ambient temperature with Co2 (CO) 8 in TFA:DCM. Deprotection with other transition metals like palladium have also been reported[1][2]. H-L-Phe (4-NH-Poc) -OH (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[2737202-66-1]

UNSPSC

12352005

Target

ADC Linker

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/h-l-phe-4-nh-poc-oh-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

OC([C@@H](N)CC1=CC=C(C=C1)NC(OCC#C)=O)=O.Cl

Molecular Formula

C13H15ClN2O4

Molecular Weight

298.72

References & Citations

[1]Le Chevalier Isaad A, et al. Side chain-to-side chain cyclization by click reaction. J Pept Sci. 2009 Jul;15 (7) :451-4.|[2]Jiang X, et al. Recent applications of click chemistry in drug discovery. Expert Opin Drug Discov. 2019 Aug;14 (8) :779-789.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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