CPUL1
CPUL1 is a TrxR inhibitor, which shows proliferation-inhibitory and anti-metastatic activity against A549 cells. CPUL1 influences EMT (epithelial-mesenchymal transition) via inducing ROS-mediated ERK/JNK signaling by inhibiting TrxR1 enzyme activity. CPUL1 in combination with α-Lipoic Acid or Dithiodipropionic acid (HY-W014395) is more effective[1].
Product Specifications
CAS Number
2043660-80-4
UNSPSC
12352005
Target
TrxR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cpul1.html
Solubility
10 mM in DMSO
Smiles
N#CC1=C(OC2=C(C1C3=CC(Cl)=C(Cl)C=C3)C4=NC5=CC=CC=C5N=C4C=C2N)N
Molecular Formula
C22H13Cl2N5O
Molecular Weight
434.28
References & Citations
[1]Ding Q, et al. A thioredoxin reductase 1 inhibitor pyrano [3,2-a] phenazine inhibits A549 cells proliferation and migration through the induction of reactive oxygen species production. Mol Biol Rep. 2022 Sep;49 (9) :8835-8845.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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