DACN (Tos) (hydrochloride)

DACN (Tos) hydrochloride is a click chemistry reagent containing a cycloalkyne group. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions, such strain-promoted azide-alkyne cycloadditions (SPAAC) by using cycloalkynes. DACNs possesses high thermal and chemical stability along with comparable click reactivity. DACN (Tos) hydrochloride can be used for the research of molecular conjugation[1].

Product Specifications

CAS Number

[2331322-18-8]

UNSPSC

12352005

Target

ADC Linker

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/dacn-tos-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=S(C1=CC=C(C)C=C1)(N2CC#CCNCCC2)=O.Cl

Molecular Formula

C14H19ClN2O2S

Molecular Weight

314.83

References & Citations

[1]Kawasaki, et al. Synthesis of NMs-DACN: Small and Hydrophilic Click Reaction Device. Chemistry Letters. Volume: 48. Issue: 5. Pages: 495-497. Journal. 2019.