(S, R, S) -AHPC-C6-PEG3-butyl-N3
(S, R, S) -AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent containing an azide group. (S, R, S) -AHPC-C6-PEG3-butyl-N3 serves as crosslinker-E3 ligase ligand conjugate, Click reactive protein degrader building block for PROTAC research, Template for synthesis of targeted protein degrader, VH032 conjugate[1]. (S, R, S) -AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Product Specifications
CAS Number
[2300155-90-0]
UNSPSC
12352005
Target
ADC Linker; E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/s-r-s-ahpc-c6-peg3-butyl-n3.html
Solubility
10 mM in DMSO
Smiles
[N-]=[N+]=NCCCCCCOCCOCCOCCCCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)=O)=O
Molecular Formula
C38H59N7O7S
Molecular Weight
757.98
References & Citations
[1]Jiang X, et al. Recent applications of click chemistry in drug discovery. Expert Opin Drug Discov. 2019 Aug;14 (8) :779-789.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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