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(S, R, S) -AHPC-C6-PEG3-butyl-N3

(S, R, S) -AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent containing an azide group. (S, R, S) -AHPC-C6-PEG3-butyl-N3 serves as crosslinker-E3 ligase ligand conjugate, Click reactive protein degrader building block for PROTAC research, Template for synthesis of targeted protein degrader, VH032 conjugate[1]. (S, R, S) -AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[2300155-90-0]

UNSPSC

12352005

Target

ADC Linker; E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/s-r-s-ahpc-c6-peg3-butyl-n3.html

Solubility

10 mM in DMSO

Smiles

[N-]=[N+]=NCCCCCCOCCOCCOCCCCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)=O)=O

Molecular Formula

C38H59N7O7S

Molecular Weight

757.98

References & Citations

[1]Jiang X, et al. Recent applications of click chemistry in drug discovery. Expert Opin Drug Discov. 2019 Aug;14 (8) :779-789.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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