DAPOA
DAPOA is a click chemistry reagent containing an azide group. DAPOA can be used in peptide synthesis as a linker that can be further modified at the azido-groups using Staudinger ligation or click-chemistry[1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
Product Specifications
CAS Number
[2389064-43-9]
UNSPSC
12352211
Target
ADC Linker
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/dapoa.html
Solubility
10 mM in DMSO
Smiles
[N-]=[N+]=NCC(CN=[N+]=[N-])OCC(O)=O
Molecular Formula
C5H8N6O3
Molecular Weight
200.16
References & Citations
[1]Meng G, et al. Modular click chemistry libraries for functional screens using a diazotizing reagent. Nature. 2019 Oct;574 (7776) :86-89.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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