N3-TFBA-O2Oc

N3-TFBA-O2Oc is a click chemistry reagent containing an azide group and an aryl group. Aryl azides are well-known precursors of nitrenes and have been introduced by Fleet et al. as versatile photoaffinity labeling agents to probe biological receptors. This type of compounds has been used as photo-cross linker (λmax=258 nm) in estrogen receptor studies and for direct surface coating of carbon and organic based polymers[1][2][3]. N3-TFBA-O2Oc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

[1]Morris JL, et al. Aryl azide photochemistry in defined protein environments. Org Lett. 2013 Feb 15;15(4):728-31. |[2]FLEET G, et al. Affinity Labelling of Antibodies with Aryl Nitrene as Reactive Group. Nature. 1969;224:511-512. |[3]Welle, et al. Tri- and tetravalent photoactivable cross-linking agents. Thieme. 2012;44(14):2249-2254.