4-Pentynoyl-Val-Ala-PAB-PNP
4-Pentynoyl-Val-Ala-PAB-PNP is a cleavable ADC linker, that has been used to synthesis cryptophycin conjugates[1]. 4-Pentynoyl-Val-Ala-PAB-PNP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product Specifications
CAS Number
1956294-76-0
UNSPSC
12352203
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/4-pentynoyl-val-ala-pab-pnp.html
Solubility
10 mM in DMSO
Smiles
C#CCCC(N[C@@H](C(C)C)C(N[C@@H](C)C(NC(C=C1)=CC=C1COC(OC2=CC=C(C=C2)[N+]([O-])=O)=O)=O)=O)=O
Molecular Formula
C27H30N4O8
Molecular Weight
538.55
References & Citations
[1]Cedric DESSIN, et al. Cryptophycin compounds and conjugates thereof. WO2022175222
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker
Frequently Asked Questions
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