TCO-PEG3-maleimide

TCO-PEG3-maleimide (TCO-PEG3-NEM) is a click chemistry reagent. TCO-PEG3-maleimide efficiently binds TCO (trans-cyclooctene) moiety to thiol-containing molecules (such as antibodies, cysteine-containing peptides) [1].

Product Specifications

CAS Number

[1809356-72-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ADC Linker

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/tco-peg3-maleimide.html

Purity

99.9

Solubility

10 mM in DMSO

Smiles

O=C(NCCCOCCOCCOCCCNC(CCN1C(C=CC1=O)=O)=O)OC2CC/C=C\CCC2

Molecular Formula

C26H41N3O8

Molecular Weight

523.62

Precautions

H302, H315, H319, H335

References & Citations

[1]Cobley JN, et al. Catalyst-free Click PEGylation reveals substantial mitochondrial ATP synthase sub-unit alpha oxidation before and after fertilisation. Redox Biol. 2019 Sep;26:101258.