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H-L-Tyr (2-azidoethyl) -OH

H-L-Tyr (2-azidoethyl) -OH is a unnatural Tyrosine derivative. H-L-Tyr (2-azidoethyl) -OH is a click chemistry reagent containing an azide group[1][2]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

1570523-47-5

UNSPSC

12352005

Target

ADC Linker

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/h-l-tyr-2-azidoethyl-oh.html

Solubility

10 mM in DMSO

Smiles

OC([C@@H](N)CC1=CC=C(C=C1)OCCN=[N+]=[N-])=O

Molecular Formula

C11H14N4O3

Molecular Weight

250.25

References & Citations

[1]Tookmanian EM, et al. Azidoethoxyphenylalanine as a Vibrational Reporter and Click Chemistry Partner in Proteins. Chemistry. 2015 Dec 21;21 (52) :19096-103. |[2]Maza JC, et al. Synthesis and Incorporation of Unnatural Amino Acids To Probe and Optimize Protein Bioconjugations. Bioconjug Chem. 2015 Sep 16;26 (9) :1884-9.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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