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Fmoc-L-Lys (4-N3-Z) -OH

Fmoc-L-Lys (4-N3-Z) -OH is a click chemistry reagent containing an azide group. Fmoc-L-Lys (4-N3-Z) -OH acts as Lysine building-block for SPPS containing an Azide moiety as a bioorthogonal ligation handle, an infrared probe and a photo-affinity reagent. It can be decaged by trans-cyclooctenols via a strain-promoted 1,3-dipolar cycloaddition[1][2]. Fmoc-L-Lys (4-N3-Z) -OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

1446511-14-3

UNSPSC

12352005

Target

ADC Linker

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/fmoc-l-lys-4-n3-z-oh.html

Solubility

10 mM in DMSO

Smiles

O=C(O)[C@H](CCCCNC(OCC1=CC=C(N=[N+]=[N-])C=C1)=O)NC(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O

Molecular Formula

C29H29N5O6

Molecular Weight

543.57

References & Citations

[1]Ge Y, et al. A genetically encoded multifunctional unnatural amino acid for versatile protein manipulations in living cells. Chem Sci. 2016 Dec 1;7 (12) :7055-7060. |[2]Wesalo JS, et al. Phosphine-Activated Lysine Analogues for Fast Chemical Control of Protein Subcellular Localization and Protein SUMOylation. Chembiochem. 2020 Jan 15;21 (1-2) :141-148.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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