Z-L-Aha-OH

Z-L-Aha-OH is a click chemistry reagent containing azide group[1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[1263047-43-3]

UNSPSC

12352005

Hazard Statement

H301-H311-H331-H341

Target

ADC Linker

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/z-l-aha-oh.html

Solubility

10 mM in DMSO

Smiles

O=C(OCC1=CC=CC=C1)N[C@H](C(O)=O)CCN=[N+]=[N-]

Molecular Formula

C12H14N4O4

Molecular Weight

278.26

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P403+P233-P405-P501

References & Citations

[1]Neilsen PM, et al. New 26S proteasome inhibitors with high selectivity for chymotrypsin-like activity and p53-dependent cytotoxicity. ACS Chem Biol. 2013 Feb 15;8 (2) :353-9.