PI3K/VEGFR2-IN-1

PI3K/VEGFR2-IN-1 is a potent dual PI3K/VEGFR2 inhibitor with IC50 values of 2.21 and 68 μM for PI3K and VEGFR2, respectively. PI3K/VEGFR2-IN-1 induces apoptosis. PI3K/VEGFR2-IN-1 can be used in research of cancer[1].

Product Specifications

CAS Number

[2851067-08-6]

UNSPSC

12352005

Target

Apoptosis; PI3K; VEGFR

Type

Reference compound

Related Pathways

Apoptosis; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pi3k-vegfr2-in-1.html

Solubility

10 mM in DMSO

Smiles

S=C(N/N=C(C1=CC2=CC=CC=C2O1)\C)NC3=CC=C(Cl)C=C3

Molecular Formula

C17H14ClN3OS

Molecular Weight

343.83

References & Citations

[1]El-Khouly OA, et, al. Design, synthesis and computational study of new benzofuran hybrids as dual PI3K/VEGFR2 inhibitors targeting cancer. Sci Rep. 2022 Oct 12;12 (1) :17104.