Syk-IN-6
Product Specifications
CAS Number
3018859-95-2
UNSPSC Description
Syk-IN-6 is an inhibitor of the lipid-SH2 domain interaction, control the cellular activity of kinases containing SH2 domain. Syk-IN-6 blocks Syk kinase activity, which associated hematopoietic malignancies, including acute myeloid leukemia (AML)[1].
Target Antigen
ERK; STAT; Syk
Type
Reference compound
Related Pathways
JAK/STAT Signaling;MAPK/ERK Pathway;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/syk-in-6.html
Solubility
10 mM in DMSO
Smiles
O=C(C(C(NC1=NC=CC=N1)C2=CNC3=C2C=CC=C3)=[N+]=[N-])OC4CCCCC4
Molecular Weight
390.44
References & Citations
[1]Singaram I, et al. Targeting lipid-protein interaction to treat Syk-mediated acute myeloid leukemia. Nat Chem Biol. 2022 Oct 13.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
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