PARP-2-IN-2

PARP-2-IN-2 (compound 27) is a PARP 2 inhibitor with an IC50 value of 0.057 μM. PARP-2-IN-2 induces cell cycle arrest and apoptosis of MCF-7 breast cancer cells. PARP-2-IN-2 can be used for the research of cancer[1].

Product Specifications

CAS Number

[2915651-00-0]

UNSPSC

12352005

Target

Apoptosis; PARP

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/parp-2-in-2.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC=C(C2=NC3=CC(Cl)=CC=C3O2)C=C1)CCN(CC)CC

Molecular Formula

C20H22ClN3O2

Molecular Weight

371.86

References & Citations

[1]El-Ghobashy NM, et al. Synthesis, biological evaluation, and molecular modeling studies of new benzoxazole derivatives as PARP-2 inhibitors targeting breast cancer. Sci Rep. 2022 Sep 28;12 (1) :16246.