SEH inhibitor-12
SEH inhibitor-12 (compound 34) is a sEH inhibitor with an IC50 value of 0.7 μM. sEH inhibitor-12 inhibits the 5-lipoxygenase-activating protein (FLAP) -mediated leukotriene (LT) biosynthesis with an IC50 value of 2.9 μM. sEH inhibitor-12 can be used for the research of inflammation[1].
Product Specifications
UNSPSC
12352005
Target
Epoxide Hydrolase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/seh-inhibitor-12.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(N=C(SCC2=CC=CC=C2Cl)N3)=C(C=C1)C3=O)NCC(C)(C)C
Molecular Formula
C21H22ClN3O2S
Molecular Weight
415.94
References & Citations
[1]Turanlı S, et al. Quinazoline-4 (3H) -one-7-carboxamide Derivatives as Human Soluble Epoxide Hydrolase Inhibitors with Developable 5-Lipoxygenase Activating Protein Inhibition. ACS Omega. 2022 Oct 5;7 (41) :36354-36365.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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