Pks13-TE inhibitor 3
Pks13-TE inhibitor 3 (compound 23) is a 13-Thioesterase (Pks13-TE) inhibitor (IC50=1.55 μM) . Pks13-TE inhibitor 3 shows good anti-tuberculosis activity against both agent-sensitive and drug-resistant Mtb strains (MIC=0.0625-0.25 μg/mL) . Pks13-TE inhibitor 3 can be used in studies of multidrug-resistant TB and extensively drug-resistant TB[1].
Product Specifications
CAS Number
3031462-62-8
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pks13-te-inhibitor-3.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(OC3=CC=C(O)C(CN4CCC(F)CC4)=C32)C5=C(O1)C=C(O)C=C5
Molecular Formula
C21H18FNO5
Molecular Weight
383.37
References & Citations
[1]Zhang W, et al. Structure-Based Optimization of Coumestan Derivatives as Polyketide Synthase 13-Thioesterase (Pks13-TE) Inhibitors with Improved hERG Profiles for Mycobacterium tuberculosis Treatment. J Med Chem. 2022 Oct 13;65 (19) :13240-13252.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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