Pks13-TE inhibitor 2
Pks13-TE inhibitor 2 (compound 32) is a 13-Thioesterase (Pks13-TE) inhibitor (IC50=1.30 μM) . Pks13-TE inhibitor 2 shows good anti-tuberculosis activity against both agent-sensitive and drug-resistant Mtb strains (MIC=0.0039-0.0078 μg/mL) . Pks13-TE inhibitor 2 can be used in studies of multidrug-resistant TB and extensively drug-resistant TB[1].
Product Specifications
CAS Number
3031462-75-3
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pks13-te-inhibitor-2.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C2OC3=CC=C(OCN(C4CCCC4)C5)C5=C31)OC6=C2C=CC(O)=C6
Molecular Formula
C22H19NO5
Molecular Weight
377.39
References & Citations
[1]Zhang W, et al. Structure-Based Optimization of Coumestan Derivatives as Polyketide Synthase 13-Thioesterase (Pks13-TE) Inhibitors with Improved hERG Profiles for Mycobacterium tuberculosis Treatment. J Med Chem. 2022 Oct 13;65 (19) :13240-13252.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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