DPP IV/hCA II-IN-1
DPP IV/hCA II-IN-1 is a potent and selective dipeptidyl peptidase IV (DPP IV) and carbonic anhydrase (CA) inhibitor with an IC50 value of 0.049 μM for DPP IV and with Ki values of 0.0361, 0.0428, 0.0941, 0.1328, 0.2615, and 3.034 μM for CA II, CA VB, CA VA, CA IX, CA I, and CA IV, respectively[1].
Product Specifications
CAS Number
2836996-95-1
UNSPSC
12352005
Target
Carbonic Anhydrase; Dipeptidyl Peptidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/dpp-iv-hca-ii-in-1.html
Solubility
10 mM in DMSO
Smiles
NC(C1COC2=CC=CC=C2O1)CCOC3=CC=C(C=C3)S(=O)(N)=O
Molecular Formula
C17H20N2O5S
Molecular Weight
364.42
References & Citations
[1]Artasensi A, et, al. Discovery of a Potent and Highly Selective Dipeptidyl Peptidase IV and Carbonic Anhydrase Inhibitor as "Antidiabesity" Agents Based on Repurposing and Morphing of WB-4101. J Med Chem. 2022 Oct 6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA II; CA I; CA IX
Frequently Asked Questions
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