PfGSK3/PfPK6-IN-2
PfGSK3/PfPK6-IN-2 is a potent dual PfGSK3/PfPK6 (Plasmodium falciparum GSK3/PK6) inhibitor (IC50: 172 nM and 11 nM respectively) . PfGSK3/PfPK6-IN-2 can be used in the research of Malaria[1].
Product Specifications
CAS Number
2797225-47-7
UNSPSC
12352005
Target
GSK-3
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pfgsk3-pfpk6-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(NC2=NC=C(Cl)C(C3=CC=C(Cl)S3)=N2)C=C1)N4CCC(N5CCCC5)CC4
Molecular Formula
C24H25Cl2N5OS
Molecular Weight
502.46
References & Citations
[1]Galal KA, et al. Identification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial PfGSK3/PfPK6 with Activity against Blood Stage Parasites In Vitro. J Med Chem. 2022 Oct 13;65 (19) :13172-13197.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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