PfGSK3/PfPK6-IN-1
PfGSK3/PfPK6-IN-1 (compound 23e) is a potent inhibitor of plasmodial kinases PfGSK3 and PfPK6, with IC50s of 97 nM and 8 nM, respectively. PfGSK3/PfPK6-IN-1 exerts antiplasmodial activity against blood stage Pf3D7 parasites with an EC50 value of 1.4 mM[1].
Product Specifications
CAS Number
2797225-49-9
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pfgsk3-pfpk6-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCCN1CCOCC1)C2=CC=C(NC3=NC=C(Cl)C(C4=CC=C(Cl)S4)=N3)C=C2
Molecular Formula
C22H23Cl2N5O2S
Molecular Weight
492.42
References & Citations
[1]Galal KA, et al. Identification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial PfGSK3/PfPK6 with Activity against Blood Stage Parasites In Vitro. J Med Chem. 2022 Oct 13;65 (19) :13172-13197.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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