ZG1077
ZG1077 is a covalent KRAS G12C inhibitor. ZG1077 can be used in the research of non-small cell lung cancer (NSCLC) [1].
Product Specifications
CAS Number
[2670380-82-0]
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zg1077.html
Solubility
10 mM in DMSO
Smiles
O=S(C)(C1=C(N(C2=C(C(N3[C@H](CN([C@@H](C3)C)C(C=C)=O)C)=N4)C=C(C(C5=C(F)C=CC=C5O)=N2)F)C4=O)C(C6CCC6)=CC=C1)=O
Molecular Formula
C33H33F2N5O5S
Molecular Weight
649.71
References & Citations
[1]Wei-Dong Feng, et al. Process Research for ZG1077, a KRAS G12C Inhibitor. Org. Process Res. Dev. 2022, 26, 10, 2986-2996.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Curated Selection
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