SAHA-OH

SAHA-OH is a selective HDAC6 inhibitor (IC50=23 nM), shows a 10- to 47-fold selectivity for HDAC6 compared to HDAC 1, 2, 3, and 8. SAHA-OH shows anti-inflammatory activity, and attenuates macrophage apoptosis[1].

Product Specifications

CAS Number

2857098-30-5

UNSPSC

12352005

Target

Apoptosis; HDAC

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/saha-oh.html

Solubility

10 mM in DMSO

Smiles

O=C(NO)CCCCCCC(NC1=CC=C(CO)C=C1)=O

Molecular Formula

C15H22N2O4

Molecular Weight

294.35

References & Citations

[1]Nhu Truong, et al. Modified Suberoylanilide Hydroxamic Acid Reduced Drug-Associated Immune Cell Death and Organ Damage under Lipopolysaccharide Inflammatory Challenge. ACS Pharmacol. Transl. Sci. 2022.