hDHODH-IN-11
Product Specifications
UNSPSC Description
hDHODH-IN-11 is a potent human dihydroorotate dehydrogenase (hDHODH) inhibitor with an IC50 value of 7.2 nM. hDHODH-IN-11 has low cytotoxicity. hDHODH-IN-11 can be used in research of acute myeloid leukemia (AML)[1].
Target Antigen
Dihydroorotate Dehydrogenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdhodh-in-11.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C2C=CC=CN2N=C1O)NC3=CC(C)=C(OC4=CC=CC=C4)C=C3C(C)C
Molecular Weight
401.46
References & Citations
[1]Sainas S, et, al. Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Aryloxyaryl Moiety. J Med Chem. 2022 Oct 13;65(19):12701-12724.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-151560/hDHODH-IN-11-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-151560/
Clinical Information
No Development Reported
CAS Number
2396653-34-0
Curated Selection
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