SQ-3
Product Specifications
UNSPSC Description
SQ-3 is a quinoline analogue, displays moderate selectivity for α-syn aggregates (Ki=39.3 nM) over β-amyloid (Aβ) aggregates (Ki=230 nM). [18F]SQ3 has basic properties as a lead compound for the development of a useful α-syn imaging probe[1].
Target Antigen
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/sq-3.html
Solubility
10 mM in DMSO
Smiles
CN(C)C1=CC=C(/C=C/C2=NC3=CC(OCCF)=CC=C3C=C2)C=C1
Molecular Weight
336.40
References & Citations
[1]Nakagawa K, et al. Structure-Activity Relationships of Styrylquinoline and Styrylquinoxaline Derivatives as α-Synuclein Imaging Probes. ACS Med Chem Lett. 2022 Sep 26;13(10):1598-1605.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-151554/SQ-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-151554/
Clinical Information
No Development Reported
Curated Selection
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