SQ-3

SQ-3 is a quinoline analogue, displays moderate selectivity for α-syn aggregates (Ki=39.3 nM) over β-amyloid (Aβ) aggregates (Ki=230 nM) . [18F]SQ3 has basic properties as a lead compound for the development of a useful α-syn imaging probe[1].

Product Specifications

UNSPSC

12352005

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/sq-3.html

Solubility

10 mM in DMSO

Smiles

CN(C)C1=CC=C(/C=C/C2=NC3=CC(OCCF)=CC=C3C=C2)C=C1

Molecular Formula

C21H21FN2O

Molecular Weight

336.40

References & Citations

[1]Nakagawa K, et al. Structure-Activity Relationships of Styrylquinoline and Styrylquinoxaline Derivatives as α-Synuclein Imaging Probes. ACS Med Chem Lett. 2022 Sep 26;13 (10) :1598-1605.