Mtb-cyt-bd oxidase-IN-5
Mtb-cyt-bd oxidase-IN-5 (compound 1k) is a Mycobacterium tuberculosis (Mtb) cytochrome bd (cyt-bd) oxidase (MtbCyt-bd Oxidase) inhibitor with an IC50 value of 0.37 μM. Mtb-cyt-bd oxidase-IN-5 can effectively inhibit the growth of Mtb (MIC= 256 μM) . Mtb-cyt-bd oxidase-IN-5 can be used in the study of tuberculosis[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mtb-cyt-bd-oxidase-in-5.html
Solubility
10 mM in DMSO
Smiles
C/C(C)=C\CC/C(C)=C/CC/C(C)=C/CC1=C(NC2=CC(F)=CC=C2C1=O)C
Molecular Formula
C25H32FNO
Molecular Weight
381.53
References & Citations
[1]Lawer A, et al. Synthesis and Biological Evaluation of Aurachin D Analogues as Inhibitors of Mycobacterium tuberculosis Cytochrome bd Oxidase. ACS Med Chem Lett. 2022 Sep 26;13 (10) :1663-1669.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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