Mtb-cyt-bd oxidase-IN-5

Mtb-cyt-bd oxidase-IN-5 (compound 1k) is a Mycobacterium tuberculosis (Mtb) cytochrome bd (cyt-bd) oxidase (MtbCyt-bd Oxidase) inhibitor with an IC50 value of 0.37 μM. Mtb-cyt-bd oxidase-IN-5 can effectively inhibit the growth of Mtb (MIC= 256 μM) . Mtb-cyt-bd oxidase-IN-5 can be used in the study of tuberculosis[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/mtb-cyt-bd-oxidase-in-5.html

Solubility

10 mM in DMSO

Smiles

C/C(C)=C\CC/C(C)=C/CC/C(C)=C/CC1=C(NC2=CC(F)=CC=C2C1=O)C

Molecular Formula

C25H32FNO

Molecular Weight

381.53

References & Citations

[1]Lawer A, et al. Synthesis and Biological Evaluation of Aurachin D Analogues as Inhibitors of Mycobacterium tuberculosis Cytochrome bd Oxidase. ACS Med Chem Lett. 2022 Sep 26;13 (10) :1663-1669.