MRS4596
MRS4596 is a potent and selective P2X4 receptor antagonist with an IC50 value of 1.38 μM for human P2X4 receptor. MRS4596 has neuroprotective and neuro-rehabilitative activities in ischemic stroke model. MRS4596 can be used in research of ischemic stroke [1].
Product Specifications
CAS Number
2840581-38-4
UNSPSC
12352005
Target
P2X Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mrs4596.html
Solubility
10 mM in DMSO
Smiles
O=C(C1)NC(C2=CC=C(C=C2C=C3)C)=C3N(C4=CC=CC(C([N-]5)=NOC5=S)=C4)C1=O.[Na+]
Molecular Formula
C22H15N4NaO3S
Molecular Weight
438.43
References & Citations
[1]Toti KS, et al. Structure-Activity Relationship and Neuroprotective Activity of 1,5-Dihydro-2H-naphtho[1,2-b][1,4]diazepine-2,4 (3H) -diones as P2X4 Receptor Antagonists. J Med Chem. 2022 Sep 23.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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