MLKL-IN-3
MLKL-IN-3 (compound 66) is a potent MLKL (Mixed lineage kinase domain-like protein) inhibitor. MLKL-IN-3 inhibits necroptosis in HT-29 cells and acts downstream of MLKL phosphorylation, with EC50 of 31 nM[1]. MLKL-IN-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product Specifications
CAS Number
3031406-27-3
UNSPSC
12352005
Target
Mixed Lineage Kinase; Necroptosis
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mlkl-in-3.html
Solubility
10 mM in DMSO
Smiles
ClC1=C(C(N(C(N1CC#CC2=CC=C(C(CN3C=CC=C(C3=O)OC)=C2)O)=O)C)=O)NC(CCC4=CC=C(C=C4)C)=O
Molecular Formula
C31H29ClN4O6
Molecular Weight
589.04
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Human Recombinant Sirtuin 6 (SIRT6) ELISA Kit
Human Recombinant Sirtuin 6 (SIRT6) ELISA Kit
NOL4 (NM_001198549) Human Tagged ORF Clone Lentiviral Particle