MLKL-IN-3

MLKL-IN-3 (compound 66) is a potent MLKL (Mixed lineage kinase domain-like protein) inhibitor. MLKL-IN-3 inhibits necroptosis in HT-29 cells and acts downstream of MLKL phosphorylation, with EC50 of 31 nM[1]. MLKL-IN-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[3031406-27-3]

UNSPSC

12352005

Target

Mixed Lineage Kinase; Necroptosis

Type

Reference compound

Related Pathways

Apoptosis; MAPK/ERK Pathway

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mlkl-in-3.html

Solubility

10 mM in DMSO

Smiles

ClC1=C(C(N(C(N1CC#CC2=CC=C(C(CN3C=CC=C(C3=O)OC)=C2)O)=O)C)=O)NC(CCC4=CC=C(C=C4)C)=O

Molecular Formula

C31H29ClN4O6

Molecular Weight

589.04

References & Citations

[1]Cui B, et al. Discovery of a New Class of Uracil Derivatives as Potential Mixed Lineage Kinase Domain-like Protein (MLKL) Inhibitors. J Med Chem. 2022 Oct 13;65 (19) :12747-12780.